PUBLICATIONS

Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine

Wang, S. et al., Autophagy 2022 May 4;1-26

Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma.

Geva, M., et al. Scientific Reports 11, 21975 (2021)

Pridopidine reduces mutant huntingtin-induced endoplasmic reticulum stress by modulation of the Sigma-1 receptor.

Shenkman, M. et al., Journal of Neurochemistry 2021; Jul;158(2):467-481

Sigma-1 Receptor (S1R) Interaction with Cholesterol: Mechanisms of S1R Activation and Its Role in Neurodegenerative Diseases.

Zhemkov V., et al International Journal of Molecular Science 2021, 22, 4082

The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models.

Naia, L. et al., Neurotherapeutics 2021; Apr;18(2):1017-1038

Effects of Pridopidine on Functional Capacity in Early-Stage Participants from the PRIDE-HD Study

McGarry et al., Journal of Huntington’s Disease 2020; 9(4):371-380.

Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [ 18 F] fluspidine and [ 18 F] fallypride PET study

Grachev et al., European Journal of Nuclear and Molecular Medicine Imaging 2021; Apr;48(4):1103-1115

Additional Safety and Exploratory Efficacy Data at 48 and 60 Months From Open-HART, an Open-Label Extension Study of Pridopidine in Huntington Disease

McGarry et al., J Journal of Huntington’s Disease 2020; 9(2):173-184.

Pridopidine Protects Neurons from Mutant-Huntingtin Toxicity via the Sigma 1-Receptor

Eddings et al., Neurobiology of Disease 2019; 129:118-129.

Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques

Johnston et al., Movement Disorders 2019; 13:209.

Impairment and Restoration of Homeostatic Plasticity in Cultured Cortical Neurons from a Mouse Model of Huntington Disease

Smith-Dijak et al., Frontiers in Cellular Neuroscience 2019; 13:209.

Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model

Ionescu et al., Cell Death & Disease 2019; 10(3):210.

Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson’s Disease

Francardo et al., Neurotherapeutics 2019;16(2):465-479.

Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor

Ryskamp et al., Neurobiology of Disease 2018;124:489-504.

Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse

Kusko et al., Molecular Neurodegeneration 2018;13(1):25.

Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice

Garcia-Miralles et al., Journal of Clinical Investigation 2017;2(23):e95665.

The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease

Ryskamp et al., Neurobiology of Disease 2017; 97(Pt A):46-59.

Pridopidine activates neuroprotective pathways impaired in Huntington Disease

Geva et al., Human Molecular Genetics 2016; 25(18):3975-3987.